徐慧，博士，山东临沂人

邮箱：xuhuiapchy@126.com

教育经历

2016.09-2020.12，香港大学，食品与营养科学，博士

2012.09-2015.06，中国海洋大学，食品科学，硕士

2008.09-2012.06，中国海洋大学，生物科学（海洋生物学方向），学士

学术工作经历

2024.07至今，江苏科技大学，专任教师

2023.05-2024.06，深圳大学，副研究员

2021.01-2023.04，深圳大学，博士后

研究方向

1. 膳食多酚的功效评价与分子机制解析

2. 药食同源植物中功效因子的发掘及生物活性探究

项目情况

1. 柚皮素类黄烷酮化合物改善缺血性脑卒中损伤和神经再生功能的作用和机制研究，中国博士后科学基金面上项目，2021.01-2022.12，8万元，主持

2. 柚皮素衍生物抑制神经炎症并改善脑缺血再灌注损伤的作用研究，中国博士后国（境）外交流项目——引进项目，2021.01-2022.12，40万元，主持

3. 从肠道菌群角度解析陈皮黄酮对AGEs损伤的保护作用，广东省基础和应用基础面上项目，2022.01-2024.12，10万元，参与

代表性成果

1. Hui Xu, Shenglong Yu, Chunxi Lin, Dingjun Dong, Jianbo Xiao, Yanbin Ye, Mingfu Wang (2024), Roles of flavonoids in ischemic heart disease: cardioprotective effects and mechanisms against myocardial ischemia and reperfusion injury, Phytomedicine, 2024, 155409

2. Haoxie Xu, Yachao Wang, Xiangzhu Li, Xuli Wu, Louise Weiwei Lu, Jiayi He, Mingfu Wang, Bin Liu, Hui Xu*, Jie-Hua Chen*, Ka-Wing Cheng* (2024). β-1,3-glucan-rich Euglena gracilis supplementation alleviated high-fat-high-fructose diet-induced cognitive impairment in aged mice via gut-brain axis, Food Science and Human Wellness, in press

3. Hui Xu, Qian Zhou, Bin Liu, Feng Chen, Mingfu Wang (2022). Holothurian fucosylated chondroitin sulfates and their potential benefits for human health: Structures and biological activities. Carbohydrate Polymers, 275, 118691

4. Hui Xu, Jiangang Shen, Jianbo Xiao, Feng Chen, Mingfu Wang (2021). Neuroprotective effect of cajaninstilbene acid against cerebral ischemia and reperfusion damages by activating AMPK/Nrf2 pathway. Journal of Advanced Research, 34, 199–210

5. Hui Xu, Qian Zhou, Bin Liu, Ka-Wing Cheng, Feng Chen, Mingfu Wang (2021). Neuroprotective potential of mung bean (Vigna radiata L.) polyphenols in Alzheimer’s disease: A review. Journal of Agricultural and Food Chemistry, 69, 11554-11571

6. Hui Xu, Emily Wang, Feng Chen, Jianbo Xiao, Mingfu Wang (2021). Neuroprotective phytochemicals in experimental ischemic stroke: Mechanisms and potential clinical applications. Oxidative Medicine and Cellular Longevity, 2021, 6687386

7. Hui Xu, Ruixia Deng, Edmund T.S. Li, Jiangang Shen, Mingfu Wang (2020). Pinosylvin provides neuroprotection against cerebral ischemia and reperfusion injury through enhancing PINK1/Parkin mediated mitophagy and Nrf2 pathway. Journal of Functional Foods, 71, 104019

8. Hui Xu, Fei Wang, Jingfeng Wang, Jie Xu, Yuming Wang, Changhu Xue (2015). The WNT/β-catenin pathway is involved in the anti-adipogenic activity of cerebrosides from the sea cucumber Cucumaria frondosa. Food & Function, 6, 2396-2404

9. Hui Xu, Jingfeng Wang, Yaoguang Chang, Jie Xu, Yuming Wang, Tengteng Long, Changhu Xue (2014). Fucoidan from the sea cucumber Acaudina molpadioides exhibits anti-adipogenic activity by modulating the Wnt/β-catenin pathway and down-regulating the SREBP-1c expression. Food & Function, 5, 1547-1555

10. Hui Xu, Jingfeng Wang, Xin Zhang, Zhaojie Li, Yuming Wang, Changhu Xue (2015). Inhibitory effect of fucosylated chondroitin sulfate from the sea cucumber Acaudina molpadioides on adipogenesis is dependent on Wnt/β-catenin pathway. Journal of Bioscience and Bioengineering, 119, 85-91

11. Hui Xu, Jie Xu, Yiming Wang, Shiwei Hu, Yuming Wang, Jingfeng Wang, Changhu Xue (2015). Fucoidan isolated from the sea cucumber Acaudina molpadioides improves insulin resistance in adipocytes via activating PKB/GLUT4 pathway. European Food Research and Technology, 240, 753-761

12. Shiwei Hu^#, Hui Xu^#, Ruixi Chen, Jingfeng Wang, Zhaojie Li, Jiachao Xu (2014). Activation of PKB and ERK, but not PI3K, is involved in fucosylated chondroitin sulphate from Acaudina molpadioides induced glucose uptake. Journal of Functional Foods, 10, 385-396 (共同第一作者)

13. 徐慧，徐杰，赵延蕾，于哲，王静凤 (2017). 叶瓜参鞘脂抑制3T3-L1前脂肪细胞分化及构效关系研究. 中国食品学报，17, 17-22 (EI检索)

14. 王明福，徐慧，周倩，陈峰，刘宾，郑家荣. 黄烷酮类化合物及其制备方法和应用. 中国发明专利，已授权，ZL202210460239.1, 2023-09-22